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The role of PARP1 in the DNA damage response and its application in tumor therapy

Zhifeng Wang, Fengli Wang, Tieshan Tang, Caixia Guo

Frontiers of Medicine 2012, Volume 6, Issue 2,   Pages 156-164 doi: 10.1007/s11684-012-0197-3

Abstract:

Single-strand break repair protein poly(ADP-ribose) polymerase 1 (PARP1) catalyzes the poly(ADP-ribosyl)ation of many key proteins in vivo and thus plays important roles in multiple DNA damage responseThe present review will focus on recent progress on the role of PARP1 in the DNA damage response andresistance of BRCA-deficient tumors to PARP inhibitors is also briefly discussed from the perspective of DNAdamage and repair.

Keywords： PARP1     synthetic lethality     PARP inhibitor     DNA repair     cancer     NHEJ    

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Regulation and function of histone acetyltransferase MOF

Yang Yang, Xiaofei Han, Jingyun Guan, Xiangzhi Li

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 79-83 doi: 10.1007/s11684-014-0314-6

Abstract: In this study, we discuss the important roles of MOF in DNA damage repair, apoptosis, and tumorigenesis

Keywords： MOF     histone acetyltransferase     DNA damage repair     tumorigenesis     embryonic stem cells    

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Generation and repair of AID-initiated DNA lesions in B lymphocytes

Zhangguo Chen,Jing H. Wang

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 201-216 doi: 10.1007/s11684-014-0324-4

Abstract: AID induces U:G mismatch lesions in DNA that are subsequently converted into point mutations or DNA doubleThus, AID poses a threat to the genome of B cells if AID-initiated DNA lesions cannot be properly repairedreview, we focus on the molecular mechanisms that regulate the specificity of AID targeting and the repairpathways responsible for processing AID-initiated DNA lesions.

Keywords： class switch recombination     somatic hypermutation     activation-induced deaminase     DNA repair     genomic instability    

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Bacterial inactivation, DNA damage, and faster ATP degradation induced by ultraviolet disinfection

Chao Yang, Wenjun Sun, Xiuwei Ao

Frontiers of Environmental Science & Engineering 2020, Volume 14, Issue 1, doi: 10.1007/s11783-019-1192-6

Abstract: • Long amplicon is more effective to test DNA damage induced by UV. • ATP in bacteria does not degradeWe used quantitative polymerase chain reaction (qPCR) to investigate DNA damage and evaluated adenosineThe results of qPCR effectively showed the DNA damage induced by UV when using longer gene amplicons,in that sufficiently long amplicons of both 16S and gadA indicated that the UV induced DNA damages.

Keywords： UV disinfection     DNA damage     qPCR     ATP    

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Effects of DNA damage on oocyte meiotic maturation and early embryonic development

Shen YIN,Junyu MA,Wei SHEN

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 3,   Pages 185-190 doi: 10.15302/J-FASE-2014035

Abstract: DNA damage is one of the most common threats to meiotic cells.Here, we reviewed exogenous factors which could induce DNA damage.Specially, we addressed the different effects of DNA damage on mouse oocytes and embryonic developmentComplex DNA damage, double-strand breaks, represents a more difficult repair process and involves variousrepair pathways.

Keywords： DNA damage     double-strand breaks (DSBs)     oocyte     embryo    

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hydrophobic environment triggering reactive fluorescence probe to real-time monitor mitochondrial DNAdamage

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 1,   Pages 92-102 doi: 10.1007/s11705-021-2063-9

Abstract: Mitochondrial DNA has a special structure that is prone to damage resulting in many serious diseases,Therefore, the rapid and specific monitoring of mitochondrial DNA damage is urgently needed for biologicalIn this design, MBI-CN conjugates to mitochondrial DNA without causing additional damages.damage., it is a potentially effective detection tool for the real-time monitoring of mitochondrial DNA damage

Keywords： hydrolysis reaction     mitochondrial DNA damage     in situ hydrophobic environment trigger     fluorescence    

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Detection of oxidative stress and DNA damage in freshwater snail

Daoud Ali, Huma Ali, Saud Alifiri, Saad Alkahtani, Abdullah A Alkahtane, Shaik Althaf Huasain

Frontiers of Environmental Science & Engineering 2018, Volume 12, Issue 5, doi: 10.1007/s11783-018-1039-6

Abstract:

Freshwater snail (Lymnea luteola L.) is good bio indicator of water pollution.

Profenofos is tested for its molluscicidal activity against Lymnea luteola L. snail.

Deleterious effects on some oxidative stress were detected.

Profenofos has a genotoxic effect on Lymnea luteola L. snails.

Keywords： Acute toxicity     Profenofos     ROS     oxidative stress     DNA damage     Lymnea luteola    

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Correlativity study between expression of DNA double-strand break repair protein and radiosensitivity

Liang ZHUANG, Shiying YU, Xiaoyuan HUANG, Yang CAO, Huihua XIONG

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 26-29 doi: 10.1007/s11684-009-0008-7

Abstract: DNA double-strand break (DSB) is generally regarded as the most lethal of all DNA lesions after radiationKu80, DNA-PK catalytic subunit (DNA-PKcs) and ataxia telangiectasia mutated (ATM) proteins are majorDSB repair proteins.acquired by clone formation assay, and western blot was applied to detect the expressions of Ku80, DNA-PKcsThese findings suggest that the expression level of DNA-PKcs protein can be an indicator for predicting

Keywords： Ku80     DNA-PK(cs)-binding protein     human     ataxia telangiectasia mutated protein     tumor cell lines     radiosensitivity    

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Functional role of ATM in the cellular response to DNA damage

Ming LIU, Wenxiang HU

Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 2,   Pages 179-187 doi: 10.1007/s11705-009-0268-4

Abstract: Activation of ATM results in phosphorylation of many downstream targets that modulate numerous damageour understanding of the mechanism of activation of ATM and its signaling pathways, explore whether DNA

Keywords： ataxia-telangiectasia mutated (ATM)     cell cycle checkpoint     DNA damage     signalling transduction    

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Relationship between reactive oxygen species and sodium-selenite-induced DNA damage in HepG2 cells

ZOU Yunfeng, NIU Piye, GONG Zhiyong, YANG Jin, YUAN Jing, WU Tangchun, CHEN Xuemin

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 327-332 doi: 10.1007/s11684-007-0063-x

Abstract: In this study, we investigated the relationship between ROS and the levels of DNA damage induced by seleniteThe levels of DNA damage in HepG2 increased in all cells treated with an increasing dose of seleniteMoreover, NAC effectively blocked DNA damage induced by selenite.These results revealed that ROS might play an important role in selenite-induced DNA damage that can

Keywords： NAC     N-acetylcysteine     DNA     fluorescence     relationship    

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Bile duct injury repair — earlier is not better

Vinay K. Kapoor

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 508-511 doi: 10.1007/s11684-015-0418-7

Abstract: The timing of bile duct injury repair remains controversial.A recent review conducted in France reported 39% complications and 64% failure after immediate repairin 194 patients compared with 14% complications and 8% failure after late repair in 133 patients.Most patients with bile duct injury present with bile leak and sepsis; thus, early repair is not recommended

Keywords： bile duct injury     cholecystectomy     laparoscopic cholecystectomy    

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p53 functional activation is independent of its genotype in five esophageal squamous cell carcinoma cell lines

Junfang JI, Kun WU, Min WU, Qimin ZHAN,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 412-418 doi: 10.1007/s11684-010-0260-x

Abstract: To examine the potential p53 activation in a certain ESCC cell line, DNA damage methods including X-rayusing Western blot and reverse transcription-polymerase chain reaction (RT-PCR) after cell exposure to DNAdamage.showed that in KYSE 30 cell line with mutant and KYSE 150 with wild-type , p53 could be activated by DNAHowever, p53 could not be activated following the DNA damages in YES 2 with wild-type , KYSE 70 with

Keywords： p53     esophageal squamous cell carcinoma     DNA damage    

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Engineering DNA Materials for Sustainable Data Storage Using a DNA Movable-Type System Article

Zi-Yi Gong, Li-Fu Song, Guang-Sheng Pei, Yu-Fei Dong, Bing-Zhi Li, Ying-Jin Yuan

Engineering 2023, Volume 29, Issue 10,   Pages 130-136 doi: 10.1016/j.eng.2022.05.023

Abstract:

DNA molecules are green materials with great potential for high-density and long-term data storageHowever, the current data-writing process of DNA data storage via DNA synthesis suffers from high costsHere, we developed a DNA movable-type storage system that can utilize DNA fragments pre-produced by cellIn this system, these pre-generated DNA fragments, referred to herein as "DNA movable types,"the costly and environmentally hazardous process of de novo DNA synthesis.

Keywords： 合成生物学     DNA信息存储     DNA活字存储系统     经济性DNA数据存储    

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Mobile platform for hydraulic turbine blade repair robot

GUI Zhongcheng, CHEN Qiang, SUN Zhenguo, ZHANG Wenzeng, LIU Kang

Frontiers of Mechanical Engineering 2008, Volume 3, Issue 2,   Pages 164-169 doi: 10.1007/s11465-008-0035-0

Abstract: adapt to complex spatial surfaces, which satisfy the requirements of a hydraulic turbine blade in-situ repair
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Expression status of GATA3 and mismatch repair proteins in upper tract urothelial carcinoma

Yue Wang, Jinxia Zhang, Yunfan Wang, Shufang Wang, Yu Zhang, Qi Miao, Fei Gao, Huiying He

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 730-740 doi: 10.1007/s11684-019-0687-7

Abstract: GATA binding protein 3 (GATA3) and mismatch repair (MMR) deficiency contribute to the development of

Keywords： upper tract urothelial carcinoma     GATA binding protein 3     mismatch repair     microsatellite instability     prognosis    

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Title Author Date Type Operation

The role of PARP1 in the DNA damage response and its application in tumor therapy

Zhifeng Wang, Fengli Wang, Tieshan Tang, Caixia Guo

Journal Article

Regulation and function of histone acetyltransferase MOF

Yang Yang, Xiaofei Han, Jingyun Guan, Xiangzhi Li

Journal Article

Generation and repair of AID-initiated DNA lesions in B lymphocytes

Zhangguo Chen,Jing H. Wang

Journal Article

Bacterial inactivation, DNA damage, and faster ATP degradation induced by ultraviolet disinfection

Chao Yang, Wenjun Sun, Xiuwei Ao

Journal Article

Effects of DNA damage on oocyte meiotic maturation and early embryonic development

Shen YIN,Junyu MA,Wei SHEN

Journal Article

hydrophobic environment triggering reactive fluorescence probe to real-time monitor mitochondrial DNAdamage

Journal Article

Detection of oxidative stress and DNA damage in freshwater snail

Daoud Ali, Huma Ali, Saud Alifiri, Saad Alkahtani, Abdullah A Alkahtane, Shaik Althaf Huasain

Journal Article

Correlativity study between expression of DNA double-strand break repair protein and radiosensitivity

Liang ZHUANG, Shiying YU, Xiaoyuan HUANG, Yang CAO, Huihua XIONG

Journal Article

Functional role of ATM in the cellular response to DNA damage

Ming LIU, Wenxiang HU

Journal Article

Relationship between reactive oxygen species and sodium-selenite-induced DNA damage in HepG2 cells

ZOU Yunfeng, NIU Piye, GONG Zhiyong, YANG Jin, YUAN Jing, WU Tangchun, CHEN Xuemin

Journal Article

Bile duct injury repair — earlier is not better

Vinay K. Kapoor

Journal Article

p53 functional activation is independent of its genotype in five esophageal squamous cell carcinoma cell lines

Junfang JI, Kun WU, Min WU, Qimin ZHAN,

Journal Article

Engineering DNA Materials for Sustainable Data Storage Using a DNA Movable-Type System

Zi-Yi Gong, Li-Fu Song, Guang-Sheng Pei, Yu-Fei Dong, Bing-Zhi Li, Ying-Jin Yuan

Journal Article

Mobile platform for hydraulic turbine blade repair robot

GUI Zhongcheng, CHEN Qiang, SUN Zhenguo, ZHANG Wenzeng, LIU Kang

Journal Article

Expression status of GATA3 and mismatch repair proteins in upper tract urothelial carcinoma

Yue Wang, Jinxia Zhang, Yunfan Wang, Shufang Wang, Yu Zhang, Qi Miao, Fei Gao, Huiying He

Journal Article